Glycosylation is a co- and post-translational modification that is critical for the regulation of
the biophysical properties and biological activities of diverse proteins. Biosynthetic pathways …

Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical
contributor to atherosclerosis and consequently as an attractive therapeutic target for anti-…

Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical 16
contributor to atherosclerosis and consequently, as an attractive therapeutic target for anti-17 …

Glycan macro- and microheterogeneity have profound impacts on protein folding and function.
This heterogeneity can be regulated by physiological or environmental factors. However, …

Candida albicans is the most prevalent fungal pathogen of humans. The current techniques
used to construct C. albicans strains require integration of exogenous DNA at ectopic …

The success of Candida albicans as a major human fungal pathogen is dependent on its
ability to colonize and survive as a commensal on diverse mucosal surfaces. One trait required …

Epigenetic mechanisms regulate the expression of virulence traits in diverse pathogens,
including protozoan and fungi. In the human fungal pathogen Candida albicans, virulence traits …

Monoclonal antibodies (mAbs) are one of the most successful and versatile protein-based
pharmaceutical products used to treat multiple pathological conditions. The remarkable …

Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of
these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill …

Coagulation factor IX (FIX) is a complex post-translationally modified human serum glycoprotein
and high-value biopharmaceutical. The quality of recombinant FIX (rFIX), especially …