[HTML][HTML] COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study

…, E Khan, P Mehta, L Martin-Gutierrez… - The Lancet …, 2020 - thelancet.com
Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function

…, I Ivanova, L Martin-Gutierrez… - Proceedings of the …, 2021 - National Acad Sciences
The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and
phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including lipid …

[PDF][PDF] Impaired LXRα phosphorylation attenuates progression of fatty liver disease

…, MC Gage, M Voisin, E Shrestha, L Martin-Gutierrez… - Cell reports, 2019 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation.
How fat-rich diets promote progression from fatty liver to more damaging inflammatory …

[PDF][PDF] Stratification of patients with Sjögren's syndrome and patients with systemic lupus erythematosus according to two shared immune cell signatures, with potential …

L MartinGutierrez, J Peng, NL Thompson… - Arthritis & …, 2021 - Wiley Online Library
Objective Similarities in the clinical and laboratory features of primary Sjögren’s syndrome (SS)
and systemic lupus erythematosus (SLE) have led to attempts to treat patients with …

[HTML][HTML] Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

E Gentilotti, A Górska, A Tami, R Gusinow… - …, 2023 - thelancet.com
Background Lack of specific definitions of clinical characteristics, disease severity, and risk
and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and …

[HTML][HTML] Multi-omic biomarkers for patient stratification in sjogren's syndrome—a review of the literature

L Martin-Gutierrez, R Wilson, M Castelino, EC Jury… - Biomedicines, 2022 - mdpi.com
Sjögren’s syndrome (SS) is a heterogeneous autoimmune rheumatic disease (ARD) characterised
by dryness due to the chronic lymphocytic infiltration of the exocrine glands. Patients …

Diet and lupus: what do the patients think?

…, T Mcdonnell, C Wincup, L Martin-Gutierrez… - Lupus, 2019 - journals.sagepub.com
Objectives Cardiovascular disease is the leading cause of mortality in patients with systemic
lupus erythematosus. Therefore, using diet to control blood lipid levels and modify …

[PDF][PDF] Blood metabolomic and transcriptomic signatures stratify patient subgroups in multiple sclerosis according to disease severity

…, L Coelewij, G Robertson, L Martin-Gutierrez… - iScience, 2024 - cell.com
There are no blood-based biomarkers distinguishing patients with relapsing-remitting (RRMS)
from secondary progressive multiple sclerosis (SPMS) although evidence supports …

Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis

L Martin-Gutierrez, KE Waddington… - Clinical and …, 2024 - academic.oup.com
Altered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood,
cerebrospinal fluid, and brain tissue of people with relapsing remitting multiple sclerosis (…

OA11 Juvenile Sjögren's syndrome is characterised by dysregulated of B and T memory cell frequencies: a pilot immunophenotyping analysis of this rare disease …

L Martin-Gutierrez, H Peckham, A Radziszewska… - …, 2023 - academic.oup.com
Background/Aims Sjögren’s syndrome (SS) is an autoimmune rheumatic disease characterised
by dryness resulting from chronic lymphocytic infiltration of the exocrine glands and extra …