Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR).
AREG plays a central role in mammary gland development and branching morphogenesis in …

A new efficient type of gadolinium-based theranostic agent (AGuIX®) has recently been
developed for MRI-guided radiotherapy (RT). These new particles consist of a polysiloxane …

Nanoparticles are efficient to safely deliver therapeutic and imaging contrast agents to
tumors for cancer diagnostic and therapy, if they can escape the reticuloendothelial system (RES) …

Over the past two decades, nanoparticles have been developed in the field of theranostic [1,
2] with the objective of meeting three requirements: 1) to exhibit long circulation in body …

Integrin α v β 3 is overexpressed on neoendothelial cells and frequently on tumor cells. We
have developed a peptide-like scaffold (regioselectively addressable functionalized template…

New, ultrasmall nanoparticles with sizes below 5 nm have been obtained. These small rigid
platforms (SRP) are composed of a polysiloxane matrix with DOTAGA (1,4,7,10‐…

We previously reported the synthesis of gadolinium-based nanoparticles (NPs) denoted
AGuIX (activation and guiding of irradiation by X-ray) NPs and demonstrated their potential as …

Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy.
Gadolinium (Gd) is particularly attractive because this element is also a positive contrast …

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of
curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-…