International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
…, N Gangat, U Gianelli, LA Godley… - Blood, The Journal …, 2022 - ashpublications.org
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
[PDF][PDF] Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
…, E Paietta, B Löwenberg, JD Licht, LA Godley… - Cancer cell, 2010 - cell.com
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and
resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large …
resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large …
[PDF][PDF] Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …
significant proportion of patients with myeloid malignancies. Although there are extensive …
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
…, L Zhang, TJ Looney, B Zhang, LA Godley… - Nature …, 2011 - nature.com
In contrast to 5-methylcytosine (5-mC), which has been studied extensively 1 , 2 , 3 , little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
…, BL Ebert, P Fenaux, LA Godley… - Blood, The Journal …, 2022 - ashpublications.org
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized …
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and
by increased risk of myeloid malignancies. Exome sequencing of three elderly females with …
by increased risk of myeloid malignancies. Exome sequencing of three elderly females with …
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
…, AI Levey, A Vasanthakumar, LA Godley… - Nature …, 2011 - nature.com
DNA methylation dynamics influence brain function and are altered in neurological
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5-methylcytosine, …
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5-methylcytosine, …
Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
…, MS Tallman, G Meloni, LA Godley… - Blood, The Journal …, 2011 - ashpublications.org
In a randomized trial of therapy for FMS-like tyrosine kinase-3 (FLT3) mutant acute myeloid
leukemia in first relapse, 224 patients received chemotherapy alone or followed by 80 mg of …
leukemia in first relapse, 224 patients received chemotherapy alone or followed by 80 mg of …
[PDF][PDF] Inherited and somatic defects in DDX41 in myeloid neoplasms
…, N Nguyen, S Mukherjee, C Pabst, LA Godley… - Cancer cell, 2015 - cell.com
Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …