Quantitative label-free mass spectrometry is increasingly used to analyze the proteomes of
complex biological samples. However, the choice of appropriate data analysis methods …

Label-free shotgun proteomics is routinely used to assess proteomes. However, extracting
relevant information from the massive amounts of generated data remains difficult. This …

Label-Free Quantitative mass spectrometry based workflows for differential expression (DE)
analysis of proteins impose important challenges on the data analysis because of peptide-…

The key benefits of moFF are (i) its OS independence, its ability to be run (ii) locally with a
simple graphical user interface (GUI) or (iii) on a cluster as a scriptable command line, and (iv) …

Mitochondrial dysfunction is associated with aging‐mediated inflammatory responses, leading
to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain poorly …

Organisms respond to mitochondrial stress by activating multiple defense pathways, including
the mitochondrial unfolded protein response (UPR mt ). However, how UPR mt regulators …

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe
muscle disorder, causing muscle weakness, loss of independence, and premature death. Here…

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones
that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, …

Non-alcoholic steatohepatitis (NASH) is a global health concern without treatment. The
challenge in finding effective therapies is due to the lack of good mouse models and the …