Charcot-Marie-Tooth disease (CMT) is the most common inherited neuromuscular disease
and is characterized by considerable clinical and genetic heterogeneity 1 . We previously …

Cellular compartments and organelles organize biological matter. Most well-known organelles
are separated by a membrane boundary from their surrounding milieu. There are also …

Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral
nervous system. Mutations in the 27-kDa small heat-shock protein gene (HSPB1) cause …

TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to
50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in …

Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Unfortunately and despite all efforts, amyotrophic lateral sclerosis (ALS) remains an incurable
neurodegenerative disorder characterized by the progressive and selective death of motor …

Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the
hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here, we …

C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by …

Neurotrophin treatment has so far failed to prolong the survival of individuals affected with
amyotrophic lateral sclerosis (ALS), an incurable motoneuron degenerative disorder. Here we …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due
to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can …