Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
AJ Wolf, L Desvignes, B Linas, N Banaiee… - The Journal of …, 2008 - rupress.org
The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed
compared with that of other infections or immunization, and allows the bacterial population in the …
compared with that of other infections or immunization, and allows the bacterial population in the …
[PDF][PDF] Interferon-γ-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
L Desvignes, JD Ernst - Immunity, 2009 - cell.com
Immunity to Mycobacterium tuberculosis in humans and in mice requires interferon gamma (IFN-γ).
Whereas IFN-γ has been studied extensively for its effects on macrophages in …
Whereas IFN-γ has been studied extensively for its effects on macrophages in …
[PDF][PDF] Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells
R Blomgran, L Desvignes, V Briken, JD Ernst - Cell host & microbe, 2012 - cell.com
Mycobacterium tuberculosis promotes its replication by inhibiting the apoptosis of infected
macrophages. A proapoptotic M. tuberculosis mutant lacking nuoG, a subunit of the type I …
macrophages. A proapoptotic M. tuberculosis mutant lacking nuoG, a subunit of the type I …
[HTML][HTML] Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome
…, E De Wit, AM Schmidt, B Shopsin, L Desvignes… - Nature …, 2021 - nature.com
Respiratory failure is associated with increased mortality in COVID-19 patients. There are
no validated lower airway biomarkers to predict clinical outcome. We investigated whether …
no validated lower airway biomarkers to predict clinical outcome. We investigated whether …
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CLpro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19
…, RA Prescott, AM Valero-Jimenez, L Desvignes… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …
Beyond macrophages: the diversity of mononuclear cells in tuberculosis
S Srivastava, JD Ernst, L Desvignes - Immunological reviews, 2014 - Wiley Online Library
M ycobacterium tuberculosis, the bacterium that causes tuberculosis ( TB ), is an intracellular
pathogen of mononuclear phagocytes. Although M . tuberculosis has traditionally been …
pathogen of mononuclear phagocytes. Although M . tuberculosis has traditionally been …
Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis
L Desvignes, AJ Wolf, JD Ernst - The Journal of Immunology, 2012 - journals.aai.org
Although the protective role of type II IFN, or IFN-γ, against Mycobacterium tuberculosis has
been established, the effects of type I IFNs are still unclear. One potential confounding factor …
been established, the effects of type I IFNs are still unclear. One potential confounding factor …
[HTML][HTML] Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities
…, I Aifantis, J Cangiarella, MJ Mulligan, L Desvignes… - Scientific Reports, 2021 - nature.com
Understanding antibody responses to SARS-CoV-2 is indispensable for the development of
containment measures to overcome the current COVID-19 pandemic. Recent studies …
containment measures to overcome the current COVID-19 pandemic. Recent studies …
[HTML][HTML] STIM1 controls T cell–mediated immune regulation and inflammation in chronic infection
L Desvignes, C Weidinger, P Shaw… - The Journal of …, 2015 - Am Soc Clin Investig
Chronic infections induce a complex immune response that controls pathogen replication,
but also causes pathology due to sustained inflammation. Ca 2+ influx mediates T cell …
but also causes pathology due to sustained inflammation. Ca 2+ influx mediates T cell …
[HTML][HTML] A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8
Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost, …
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost, …