Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the
etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-…

Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey of …

Background Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has the
ability to persist in its human host for exceptionally long periods of time. However, little is …

Tuberculosis (TB) is a major public health problem. One-third of the world's population is
estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent causing …

Background Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of
the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the …

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations
on a short time scale. Here, we challenge that view by demonstrating that the infection of …

Background Interplays between Mycobacterium tuberculosis, the etiological agent of
tuberculosis (TB) in human and host professional phagocytes, namely macrophages (Mϕs) and …

Background Transcriptional profiling using microarrays provides a unique opportunity to
decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able …

Dendritic cells (DCs) are likely to play a key role in immunity against Mycobacterium tuberculosis,
but the fate of the bacterium in these cells is still unknown. Here we report that, unlike …

DNA methylation is considered to be a relatively stable epigenetic mark. However, a growing
body of evidence indicates that DNA methylation levels can change rapidly; for example, in …