Binding of mammalian transcription factors (TFs) to regulatory regions is hindered by
chromatin compaction and DNA methylation of their binding sites. Nevertheless, pioneer …

In eukaryotic genomes, DNA is condensed in the form of chromatin. While chromatin is
fundamentally a protective structure, it constitutes a challenge for all major cellular functions, for …

Expanded CAG/CTG repeats underlie 13 neurological disorders, including myotonic
dystrophy type 1 (DM1) and Huntington’s disease (HD). Upon expansion, disease loci acquire …

Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor
alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex …

Estrogens are neuroprotective factors in several neurological diseases. Neuroglobin (NGB)
is one of the estrogen target genes involved in neuroprotection, but little is known about its …

The maintenance of cell identity faces many challenges during mitosis, as most DNA-binding
proteins are evicted from DNA and transcription is virtually abolished. How cells maintain …

Record #252240 English Français login Menu Search Browse Collections Help English Français
login Infoscience Details Title LBNC Formal Name (French) Laboratoire de caractérisation du …

When taking a close look at two distinct cell types within an organism, eg a mature white
adipocyte and a dopaminergic neuron, one can notice striking differences in both form and …

… I am very grateful for my colleague Ludovica Vanzan, who always supported me with
scientific advice and her friendship. Although we could not be more different in what we like or …