matrix-associated heparan sulfate proteoglycans Page 1 HIV-1 Tat protein exits from cells
via a leaderless secretory pathway and binds to extracellular matrix-associated heparan …

Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic
molecules produced by prokaryotic and eukaryotic organisms that play a key role in the …

Background Global genetic diversity of HIV-1 is a major challenge to the development of HIV
vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and …

Vaccines represent a strategic successful tool used to prevent or contain diseases with high
morbidity and/or mortality. However, while vaccines have proven to be effective in …

Tobacco use and alcohol consumption are the main risk factors associated with head and
neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Hepatocarcinogenesis is a multistep process mainly associated with persistent infection with …

Prolonged infection of uterine cervix epithelium with human papillomavirus (HPV) and
constitutive expression of viral oncogenes have been recognized as the main cause of the …

Vaccines targeting pathogens are generally effective and protective because based on
foreign non-self antigens which are extremely potent in eliciting an immune response. On the …

Cervical cancer arises from cells localized in the ectoendocervical squamocolumnar
junction of the cervix persistently infected with one of about 13 human papillomavirus (HPV) …

Background The development of cancer immunotherapeutic strategies relies on the identification
and validation of optimal target tumor antigens, which should be tumor-specific as well …