User profiles for Luis B. Barreiro
Luis BarreiroProfessor, University of Chicago. Verified email at uchicago.edu Cited by 18996 |
[PDF][PDF] Herd immunity: understanding COVID-19
HE Randolph, LB Barreiro - Immunity, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
associated disease, COVID-19, has demonstrated the devastating impact of a novel, …
associated disease, COVID-19, has demonstrated the devastating impact of a novel, …
[HTML][HTML] Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers. …
innate immune system can also result in enhanced responsiveness to subsequent triggers. …
[PDF][PDF] BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis
The dogma that adaptive immunity is the only arm of the immune response with memory
capacity has been recently challenged by several studies demonstrating evidence for memory-…
capacity has been recently challenged by several studies demonstrating evidence for memory-…
Natural selection has driven population differentiation in modern humans
The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …
in part, distinctive processes of natural selection and adaptation to variable environmental …
Integration of genetic and immunological insights into a model of celiac disease pathogenesis
Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible
individuals by exposure to cereal gluten proteins. This review integrates insights from …
individuals by exposure to cereal gluten proteins. This review integrates insights from …
[HTML][HTML] Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
From evolutionary genetics to human immunology: how selection shapes host defence genes
LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …
selective pressure on the human genome. Data from population genetic studies, including …
[HTML][HTML] Evolution of immune genes is associated with the Black Death
…, J Pizarro-Cerdá, HN Poinar, LB Barreiro - Nature, 2022 - nature.com
Infectious diseases are among the strongest selective pressures driving human evolution 1 ,
2 . This includes the single greatest mortality event in recorded history, the first outbreak of …
2 . This includes the single greatest mortality event in recorded history, the first outbreak of …
Social networks predict gut microbiome composition in wild baboons
10.7554/eLife.05224.001 Social relationships have profound effects on health in humans and
other primates, but the mechanisms that explain this relationship are not well understood. …
other primates, but the mechanisms that explain this relationship are not well understood. …
[HTML][HTML] Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
Infectious diseases have been paramount among the threats to health and survival throughout
human evolutionary history. Natural selection is therefore expected to act strongly on host …
human evolutionary history. Natural selection is therefore expected to act strongly on host …