The importance of electrical and molecular signaling through connexin (Cx) channels is now
widely recognized. The transfer of ions and other small molecules between adjacent cells is …

Connexins are thought to solely mediate cell-to-cell communication by forming gap junction
channels composed of two membrane-spanning hemichannels positioned end-to-end. …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

Gap junctions are formed by a family of homologous proteins termed connexins. Their channels
are dodecamers, and homomeric forms differ in their properties with respect to control by …

In addition to forming gap-junction channels, a subset of connexins (Cxs) also form functional
hemichannels. Most hemichannels are activated by depolarization, and opening depends …

Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older
patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic …

Neurotransmission through electrical synapses plays an important role in the spike synchrony
among neurons and oscillation of neuronal networks. Indeed, electrical transmission has …

Connexin-43 (Cx43), a gap junction protein involved in control of cell proliferation, differentiation
and migration, has been suggested to have a role in hematopoiesis. Cx43 is highly …

X‐linked Charcot‐Marie‐Tooth disease is one of a set of diseases caused by mutations in
gap junction proteins called connexins. We identified a connexin32 missense mutation (F235C…

Hexamers of connexins (Cxs) form hemichannels that dock tightly in series via their extracellular
domains to give rise to gap junction channels. Here we examined the ability of a variety …