Mammalian cells treated with ultraviolet (UV) light provide one of the best-known experimental
systems for depicting the biological consequences of DNA damage. UV irradiation …

The combination of induced pluripotent stem cell (iPSC) technology and targeted gene
modification by homologous recombination (HR) represents a promising new approach to …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed
fates such as neurons, muscle and liver is a powerful approach for understanding key …

Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of
human cancer. In this study, we investigated the early consequences of inactivating Rb in the …

10.7554/eLife.18648.001 Aging is a major risk factor in many forms of late-onset neurodegenerative
disorders. The ability to recapitulate age-related characteristics of human neurons in …

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication
forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads …

Glioblastoma multiforme is the most severe form of brain cancer. First line therapy includes
the methylating agent temozolomide and/or the chloroethylating nitrosoureas [1-(2-chloroethyl…

Telomere biology disorders (TBDs) are a group of rare diseases caused by mutations that
impair telomere maintenance. Mutations that cause reduced levels of TERC/hTR, the …

… Author links open overlay panel Luis FZ Batista 1 , Steven E … LF Batista, MF Pech, FL Zhong,
HN Nguyen, KT Xie, AJ Zaug, SM … FL Zhong, LF Batista, A. Freund, MF Pech, AS Venteicher, …