Since the first cases of AIDS appeared in 1981, human immunodeficiency virus type 1 (HIV-1)
infection has reached pandemic proportions. Forty years later, research has led to the …

The introduction of potent combination therapies in the mid-90s had a tremendous effect on
AIDS mortality. However, drug resistance has been a major factor contributing to …

Antiretroviral therapy has led to a significant decrease in human immunodeficiency virus (HIV)-related
mortality. Approved antiretroviral drugs target different steps of the viral life cycle …

Amino acid sequences have been compared for thermophilic and mesophilic molecules
from six different protein families, which include lactate and glyceraldehyde-3-phosphate …

During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Highlights • Five nucleoside inhibitors of HBV polymerase have been approved for clinical
use. • HBV polymerase protein priming activity is inhibited by purine analogs. • Entecavir and …

Human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitors can be classified
into nucleoside and nonnucleoside RT inhibitors. Nucleoside RT inhibitors are converted to …

Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif
and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide …

BHK-21 cells persistently infected with foot-and-mouth disease virus (FMDV) can be cured
of virus by treatment with the antiviral nucleoside analogue ribavirin. To study whether the …

Sin a I, a 2‐S albumin from the seeds of yellow mustard, is herein described as the major
allergen of these seeds. This protein is composed of two disulfide‐linked polypeptide chains of …