Trogocytosis is an active process that transfers surface material from targeted to effector
cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen …

Immune checkpoint therapy has resulted in remarkable improvements in the outcome for
certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a strategy …

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma
stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not …

Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is promising, with
early-phase clinical studies showing encouraging responses. However, the transcriptional …

Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that
excludes transmembrane molecules required for endosome - lysosome recruitment. Thus, the …

Purpose: Natural killer (NK)-cell recognition and function against NK-resistant cancers remain
substantial barriers to the broad application of NK-cell immunotherapy. Potential solutions …

Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas
phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize …

Toxoplasma gondii infects both hematopoietic and nonhematopoietic cells and can cause
cerebral and ocular toxoplasmosis, as a result of either congenital or postnatally acquired …

Natural killer (NK) cells are innate lymphocytes recognized for their important role against
tumor cells. NK cells expressing chimeric antigen receptors (CARs) have enhanced effector …

Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells
kill the protozoan. Thus, the parasite must avoid autophagic targeting to survive. Here we …