In basic neuroscience research, data are often clustered or collected with repeated measures,
hence correlated. The most widely used methods such as t test and ANOVA do not take …

Precision oncology involves identifying drugs that will effectively treat a tumor and then
prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy drugs …

Background A living cell has a complex, hierarchically organized signaling system that encodes
and assimilates diverse environmental and intracellular signals, and it further transmits …

Objectives A better dosing strategy can improve clinical outcomes for patients. We sought to
compare the extended or continuous infusion with conventional intermittent infusion of …

Recent anatomical evidence suggests a functionally significant back-projection pathway
from the subiculum to the CA1. Here we show that the afferent circuitry of CA1-projecting …

SF 6 is a potent greenhouse gas, and there has been research into more environmental friendly
alternative gases with the aim of replacing the use of SF 6 gas in high-voltage equipment…

Regulatory T (T reg ) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor
immune tolerance and tumorigenesis. The molecular apparatus that drives T reg cell and CAF …

The cGAS-STING cytosolic DNA sensing pathway is critical for host defense. Here, we
report that cGAS-STING–dependent type 1 interferon (IFN) response drives intestinal …

Subanesthetic ketamine evokes rapid and long-lasting antidepressant effects in human
patients. The mechanism for ketamine's effects remains elusive, but ketamine may broadly …

Background One year of adjuvant trastuzumab treatment is the standard of care for early
stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients; …