User profiles for Luka A. Clarke
 | Luka A. ClarkeBIOISI: Biosystems & Integrative Sciences Institute, University of Lisbon, Portugal Verified email at fc.ul.pt Cited by 2049 |
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei
We investigated in different human cell types nuclear positioning and transcriptional regulation
of the functionally unrelated genes GASZ, CFTR, and CORTBP2, mapping to adjacent …
of the functionally unrelated genes GASZ, CFTR, and CORTBP2, mapping to adjacent …
Correction of a cystic fibrosis splicing mutation by antisense oligonucleotides
Cystic fibrosis (CF), the most common life‐threatening genetic disease in Caucasians, is
caused by ∼2,000 different mutations in the CF transmembrane conductance regulator (CFTR) …
caused by ∼2,000 different mutations in the CF transmembrane conductance regulator (CFTR) …
[HTML][HTML] Measurements of functional responses in human primary lung cells as a basis for personalized therapy for cystic fibrosis
Background The best investigational drug to treat cystic fibrosis (CF) patients with the most
common CF-causing mutation (F508del) is VX-809 (lumacaftor) which recently succeeded in …
common CF-causing mutation (F508del) is VX-809 (lumacaftor) which recently succeeded in …
[HTML][HTML] Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies
Background Microarray studies related to cystic fibrosis (CF) airway gene expression have
gone some way in clarifying the complex molecular background of CF lung diseases, but …
gone some way in clarifying the complex molecular background of CF lung diseases, but …
[HTML][HTML] BO-LSTM: classifying relations via long short-term memory networks along biomedical ontologies
Background Recent studies have proposed deep learning techniques, namely recurrent
neural networks, to improve biomedical text mining tasks. However, these techniques rarely …
neural networks, to improve biomedical text mining tasks. However, these techniques rarely …
[HTML][HTML] Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition
Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis
Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent …
Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent …
Human epididymis protein 4: a novel serum inflammatory biomarker in cystic fibrosis
Background Increased expression of the human epididymis protein 4 (HE4) was previously
described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, …
described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, …
[HTML][HTML] Extracting microRNA-gene relations from biomedical literature using distant supervision
Many biomedical relation extraction approaches are based on supervised machine learning,
requiring an annotated corpus. Distant supervision aims at training a classifier by …
requiring an annotated corpus. Distant supervision aims at training a classifier by …
[HTML][HTML] High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets
Dysfunction of ENaC, the epithelial sodium channel that regulates salt and water reabsorption
in epithelia, causes several human diseases, including cystic fibrosis (CF). To develop a …
in epithelia, causes several human diseases, including cystic fibrosis (CF). To develop a …
TMEM16A chloride channel does not drive mucus production
Airway mucus obstruction is the main cause of morbidity in cystic fibrosis, a disease caused
by mutations in the CFTR Cl − channel. Activation of non-CFTR Cl − channels such as …
by mutations in the CFTR Cl − channel. Activation of non-CFTR Cl − channels such as …