Single-cell RNA sequencing (scRNA-seq) has enabled researchers to study gene expression
at a cellular resolution. However, noise due to amplification and dropout may obstruct …

Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common
drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to …

There is little data considering relationships among human RNA, demographic variables,
and primary human cell physiology. The platelet RNA and expression-1 study measured …

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We
explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) …

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung
cell types in health and disease is currently revolutionizing the identification of disease …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas.
Here we challenge this conclusion by showing that these studies failed to account for …