Both psychedelics and meditation exert profound modulatory effects on consciousness,
perception and cognition, but their combined, possibly synergistic effects on neurobiology are …

Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions that
lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes. The …

Meditation and psychedelics have played key roles in humankind’s search for self-transcendence
and personal change. However, neither their possible synergistic effects, nor related …

Background Sertraline is a selective serotonin reuptake inhibitor with specific indications in
child and adolescent psychiatry. Notwithstanding its frequent use and clinical benefits, the …

As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve
health outcomes, knowing the probabilistic susceptibility of developing a disorder could …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Functional magnetic resonance imaging provides rich spatio-temporal data of human brain
activity during task and rest. Many recent efforts have focussed on characterising dynamics of …

Background Pharmacological and nonpharmacological methods of inducing altered states
of consciousness (ASCs) are becoming increasingly relevant in the treatment of psychiatric …

Neuroanatomical abnormalities have been reported along a continuum from at-risk stages,
including high schizotypy, to early and chronic psychosis. However, a comprehensive …

Background Widespread white matter abnormalities are a frequent finding in chronic schizophrenia
patients. More inconsistent results have been provided by the sparser literature on at-…