… Luke C Davies … This approach has been validated by the identification of Spi-C transcriptional
networks in splenic red pulp macrophages after the discovery that Spi-C has a critical role …

Macrophages have been at the heart of immune research for over a century and are an
integral component of innate immunity. Macrophages are often viewed as terminally …

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific
functions. Many populations self-renew independently of bone marrow in the adult, …

The general paradigm is that monocytes are recruited to sites of inflammation and terminally
differentiate into macrophages. There has been no demonstration of proliferation of …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Macrophage (MØ) biology is routinely modelled in the peritoneal cavity, a vascular tissue
readily infiltrated by leukocytes during inflammation. After several decades of study, no …

Neutrophils are a vital component of immune protection, yet in cancer they may promote
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …

Control of cellular metabolism is critical for efficient cell function, although little is known
about the interplay between cell subset–specific metabolites in situ, especially in the tumor …

Inflammatory maturation of M1 macrophages by proinflammatory stimuli such as toll like
receptor ligands results in profound metabolic reprogramming resulting in commitment to …

In this Viewpoint, we concentrate on the aspects of macrophage biology that we believe are
fundamental for an appropriate contextual understanding of macrophage function during …