It has been hypothesized that a major factor in the progression of mitochondrial disease
resulting from defects in oxidative phosphorylation (OXPHOS) is the stimulation of the …

The anatomy of the mammalian visual system, from the retina to the neocortex, is organized
hierarchically 1 . However, direct observation of cellular-level functional interactions across …

Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …

To determine the importance of mitochondrial reactive oxygen species toxicity in aging and
senescence, we analyzed changes in mitochondrial function with age in mice with partial or …

The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Alzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the
brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD …

We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and cerebral
accumulation of the β-amyloid peptide (Aβ), but it is unknown what makes neurons …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties 1 , 2 …