Over the last 40 years osteosarcoma (OS) survival has stagnated with patients commonly
resistant to neoadjuvant MAP chemotherapy involving high dose methotrexate, adriamycin (…

Background Osteosarcoma (OS) is the most common type of primary bone cancer affecting
children and adolescents. OS has a high propensity to spread meaning the disease is often …

Primary bone cancer (PBC) comprises several subtypes each underpinned by distinctive
genetic drivers. This driver diversity produces novel morphological features and clinical …

RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis.
We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in …

The inaugural meeting of the EU COST Action CA21130 PRESTO was held in February 2023,
at the University of Ferrara, Italy. Our meeting report provides an overview of PRESTO, a …

Primary bone cancers are rare malignant diseases with significant morbidity and mortality.
The treatment regimen relies on a combination of surgery (often involving amputation), …

PRESTO was established in 2022 and is a concerted effort by leading European experts in
the field of P2XRs and extracellular ATP to promote and advance the transition to the clinic of …

The following article considers the approach taken by the courts of the United States in
claims concerning issues of state immunity and private international law with respect to the …

This article considers the law pertaining to no oral modification clauses under both English
and New York law, examining how the clauses have been treated under the respective legal …

The doctrine of abuse of process, as a subsidiary concept of the principle of abuse of rights,
is well established as a general principle of law and regularly invoked by member states in …