User profiles for Luke Witherspoon

Luke Witherspoon

University of Ottawa
Verified email at toh.ca
Cited by 347

[HTML][HTML] Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway

…, D MacKenzie, L Witherspoon… - The Journal of …, 2011 - Am Soc Clin Investig
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease that
is characterized by the loss of motor neurons, resulting in progressive muscle atrophy. It is …

[HTML][HTML] Clinical pearls to managing men's health conditions during the COVID-19 pandemic

L Witherspoon, R Fitzpatrick, P Patel… - Canadian Urological …, 2020 - ncbi.nlm.nih.gov
In late 2019, a novel coronavirus (Sars-CoV-2) was identified in Wuhan, China. 1 Subsequently,
the rapid spread of the coronavirus disease 2019 (COVID-19) around the world has …

Human in vitro spermatogenesis as a regenerative therapy—where do we stand?

M Robinson, S Sparanese, L Witherspoon… - Nature Reviews …, 2023 - nature.com
Spermatogenesis involves precise temporal and spatial gene expression and cell signalling
to reach a coordinated balance between self-renewal and differentiation of spermatogonial …

Using clinically derived human tissue to 3-dimensionally bioprint personalized testicular tubules for in vitro culturing: first report

M Robinson, E Bedford, L Witherspoon, SM Willerth… - F&S Science, 2022 - Elsevier
Objective To study the feasibility and spermatogenic potential of 3-dimensional (3D)
bioprinting personalized human testicular cells derived from a patient with nonobstructive …

[HTML][HTML] Automated rare sperm identification from low-magnification microscopy images of dissociated microsurgical testicular sperm extraction samples using deep …

R Lee, L Witherspoon, M Robinson, JH Lee, SP Duffy… - Fertility and …, 2022 - Elsevier
Objective To develop a machine learning algorithm to detect rare human sperm in semen
and microsurgical testicular sperm extraction (microTESE) samples using bright-field (BF) …

[HTML][HTML] Y-microdeletions: a review of the genetic basis for this common cause of male infertility

L Witherspoon, A Dergham… - … Andrology and Urology, 2021 - ncbi.nlm.nih.gov
The human Y-chromosome contains genetic material responsible for normal testis development
and spermatogenesis. The long arm (Yq) of the Y-chromosome has been found to be …

[HTML][HTML] Improving access to urologists through an electronic consultation service

L Witherspoon, C Liddy, A Afkham, E Keely… - Canadian Urological …, 2017 - ncbi.nlm.nih.gov
Methods Urology eConsults completed through the Champlain BASE service from March
2013 to January 2015 were analyzed. Each consult was characterized in regard to the type of …

It puts the T's in fertility: testosterone and spermatogenesis

L Witherspoon, R Flannigan - International Journal of Impotence …, 2022 - nature.com
The role of testosterone in successful spermatogenesis has been a well-documented
physiologic process for several decades. Like any process in the human body, there are multiple …

Evidence-based approach to active surveillance of prostate cancer

L Witherspoon, RH Breau, LT Lavallée - World Journal of Urology, 2020 - Springer
Active surveillance is a good management option for some men with non-metastatic
prostate cancer. In this review, we examine the evidence for several topics related to active …

[HTML][HTML] Is it time to rethink how we page physicians? Understanding paging patterns in a tertiary care hospital

L Witherspoon, E Nham, H Abdi, A Dergham… - BMC Health Services …, 2019 - Springer
Background Frequent pages can disrupt workflow, interrupt patient care, and may contribute
to physician burnout. We hypothesized that paging volumes followed consistent temporal …