During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of
function from the maternal allele of UBE3A, a gene encoding an E3 ubiquitin ligase. UBE3A is …

Tracking active transcription with the nuclear run-on (NRO) assays has been instrumental in
uncovering mechanisms of gene regulation. The coupling of NROs with high-throughput …

Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

Gene expression programs change during cellular transitions. It is well established that a
network of transcription factors and chromatin modifiers regulate RNA levels during embryonic …

The development of an immunocompetent model of NUT carcinoma that closely mimics the
human disease provides a valuable global resource for mechanistic and preclinical studies …

RNA-binding proteins (RBPs) form a large and diverse class of factors, many members of
which are overexpressed in hematologic malignancies. RBPs participate in various processes …

Following cell division, genomes must reactivate gene expression patterns that reflect the
identity of the cell. Here, we use PRO-seq to examine the mechanisms that reestablish …

The identity of dividing cells is challenged during mitosis, as transcription is halted and
chromatin architecture drastically altered. How cell type-specific gene expression and genomic …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of
function from the maternal allele of UBE3A, a gene encoding an E3 ubiquitin ligase. UBE3A is …