User profiles for Lunbo Tan

Lunbo Tan

Erasmus MC
Verified email at erasmusmc.nl
Cited by 254

[HTML][HTML] The role of chemerin in metabolic and cardiovascular disease: a literature review of its physiology and pathology from a nutritional perspective

L Tan, X Lu, AHJ Danser, K Verdonk - Nutrients, 2023 - mdpi.com
Chemerin is a novel adipokine that plays a major role in adipogenesis and lipid metabolism.
It also induces inflammation and affects insulin signaling, steroidogenesis and …

[HTML][HTML] Dietary supplementation of Astragalus polysaccharides enhanced immune components and growth factors EGF and IGF-1 in sow colostrum

L Tan, T Wei, A Yuan, J He, J Liu, D Xu… - Journal of Immunology …, 2017 - hindawi.com
Colostrum is the main external resource providing piglets with nutrients and maternal immune
molecules. Astragalus polysaccharides (APS) have been used as immunopotentiators in …

[HTML][HTML] Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice

B Zhang, L Tan, Y Yu, B Wang, Z Chen, J Han, M Li… - Theranostics, 2018 - ncbi.nlm.nih.gov
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking,
mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum-…

Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

L Tan, Z Chen, F Sun, Z Zhou, B Zhang, B Wang… - Clinical …, 2022 - portlandpress.com
Maternal circulating levels of the adipokine chemerin are elevated in preeclampsia, but its
origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental …

Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease

Z Jin, Y Sun, T Yang, L Tan, P Lv, Q Xu, G Tao, S Qin… - Biomaterials, 2021 - Elsevier
Metabolic dysfunction-associated fatty liver disease (MAFLD) is estimated to affect a quarter
of all population and represents a major health threat to all societies. Yet, currently no …

[HTML][HTML] Transplacental Zika virus transmission in ex vivo perfused human placentas

…, M Broekhuizen, PPA Unger, L Tan… - PLoS Neglected …, 2022 - journals.plos.org
A Zika virus (ZIKV) infection during pregnancy can result in severe birth defects such as
microcephaly. To date, it is incompletely understood how ZIKV can cross the human placenta. …

[HTML][HTML] Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia

L Tan, Z Ouyang, Z Chen, F Sun, H Guo… - Lipids in Health and …, 2023 - Springer
Background The adipokine chemerin regulates adipogenesis and the metabolic function of
both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression …

[HTML][HTML] Megalin, proton pump inhibitors and the renin–angiotensin system in healthy and pre-eclamptic placentas

Y Sun, L Tan, RI Neuman, M Broekhuizen… - International Journal of …, 2021 - mdpi.com
Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump
inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs lower …

Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia

L Tan, ACM Kluivers, EO Cruz-López… - …, 2024 - Am Heart Assoc
BACKGROUND: Chemerin, an inflammatory adipokine, is upregulated in preeclampsia,
and its placental overexpression results in preeclampsia-like symptoms in mice. Statins may …

Serum Chemerin As A Novel Biomarker For Preeclampsia Complications: Effects Of Statins On Its Release From The Placenta

L Tan, M Broekhuizen, RI Neuman… - …, 2022 - Am Heart Assoc
Background: The adipokine chemerin is increased in preeclampsia (PE), possibly because
it is released from the placenta. We aimed to evaluate the potential of chemerin as novel …