Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial
signaling pathways. Presenilin-associated rhomboid-like (PARL) is an inner mitochondrial …

The metalloprotease ADAM 10 is an important APP α-secretase candidate, but in vivo proof
of this is lacking. Furthermore, invertebrate models point towards a key role of the ADAM 10 …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder.
Mutations in presenilins 1 and 2 (PS1 and PS2) account for ∼40% of familial AD (FAD) cases. …

* Neuronal Cell Biology Laboratory, CME, KU Leuven and Flanders Interuniversitary Institute
for Biotechnology (VIB4), Herestraat 49, 3000 Leuven, Belgium† Thromb–X, NV, Herestraat …

The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations …

Mutations in the homologous presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most
common and aggressive form of familial Alzheimer’s disease. Although PS1 function and …

β-Secretase (BACE1) is the rate-limiting protease for the generation of the amyloid β-peptide
(Aβ) in Alzheimer disease. Mice in which the bace1 gene is inactivated are reported to be …

The metalloproteinase and major amyloid precursor protein (APP) α-secretase candidate
ADAM10 is responsible for the shedding of proteins important for brain development, such as …

The γ-secretase complex plays a role in Alzheimer’s disease and cancer progression. The
development of clinically useful inhibitors, however, is complicated by the role of the γ-…

In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate
and are deposited as senile plaques. A major therapeutic strategy aims to decrease …