The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout
the menstrual cycle in response to ovarian hormones. We have generated dense single-cell …

The prediction of transcription factor (TF) activities from the gene expression of their targets (ie,
TF regulon) is becoming a widely used approach to characterize the functional status of …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries 1 . Historically, limited tissue accessibility, a …

The relationship between the human placenta—the extraembryonic organ made by the fetus,
and the decidua—the mucosal layer of the uterus, is essential to nurture and protect the …

Protein phosphorylation is a key post-translational modification regulating protein function
in almost all cellular processes. Although tens of thousands of phosphorylation sites have …

Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …

Despite their importance in maintaining the integrity of all cellular pathways, the role of
mutations on protein-protein interaction (PPI) interfaces as cancer drivers has not been …

Babelomics has been running for more than one decade offering a user-friendly interface
for the functional analysis of gene expression and genomic data. Here we present its fifth …

Copy-number variations (CNVs) are ubiquitous in cancer and often act as driver events, but
the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze …

The post-translational regulation of proteins is mainly driven by two molecular events, their
modification by several types of moieties and their interaction with other proteins. These two …