Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts

L Zhu, L Nie, G Zhu, L Xiang, J Shao - Developmental & Comparative …, 2013 - Elsevier
Fish is considered to be an important model in comparative immunology studies because it
is a representative population of lower vertebrates serving as an essential link to early …

[HTML][HTML] Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation

…, DD Fan, MJ Feng, S Zhang, Q Shi, LY Zhu… - PLoS …, 2015 - journals.plos.org
The large yellow croaker Larimichthys crocea (L. crocea) is one of the most economically
important marine fish in China and East Asian countries. It also exhibits peculiar behavioral …

Highly effective and low-cost microRNA detection with CRISPR-Cas9

XY Qiu, LY Zhu, CS Zhu, JX Ma, T Hou… - ACS synthetic …, 2018 - ACS Publications
MicroRNAs have been reported as related to multiple diseases and have potential applications
in diagnosis and therapeutics. However, detection of miRNAs remains improvable, given …

B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules

L Zhu, A Lin, T Shao, L Nie, W Dong… - The Journal of …, 2014 - journals.aai.org
The long-held paradigm that B cells cannot uptake nonspecific particulate Ags for the initiation
of primary adaptive immunity has been challenged by the recent discovery that teleost B …

Essential role of IL-4 and IL-4Rα interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates

L Zhu, P Pan, W Fang, J Shao… - The Journal of Immunology, 2012 - journals.aai.org
The roles of IL-4 and IL-4Rα in Th2-mediated immunity have been well characterized in
humans and other mammals. In contrast, few reports have been documented in ancient …

Novel nucleic acid detection strategies based on CRISPR‐Cas systems: From construction to application

…, X Qiu, S Xie, W Li, L Zhu, L Zhu - Biotechnology and …, 2020 - Wiley Online Library
Beyond their widespread application as genome‐editing and regulatory tools, clustered
regularly interspaced short palindromic repeats (CRISPR)‐CRISPR‐associated (Cas) systems …

Characterization of surface phenotypic molecules of teleost dendritic cells

T Shao, LY Zhu, L Nie, W Shi, WR Dong… - Developmental & …, 2015 - Elsevier
Dendritic cells (DCs) are among the most important professional antigen-presenting cells (APCs)
that participate in various biological activities in mammals. However, evidence of the …

Negative pressure wound therapy is associated with up‐regulation of bFGF and ERK 1/2 in human diabetic foot wounds

…, R Han, Y Liu, LY Hu, XL Li, LY Zhu - Wound Repair and …, 2014 - Wiley Online Library
Chronic foot wounds are a leading cause of morbidity and hospitalization for patients with
diabetes. Negative pressure wound therapy ( NPWT ) is known to promote healing of diabetic …

Effect of negative pressure wound therapy on cellular fibronectin and transforming growth factor-β1 expression in diabetic foot wounds

SL Yang, LY Zhu, R Han, LL Sun… - Foot & Ankle …, 2017 - journals.sagepub.com
Background: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and
hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can …

[HTML][HTML] Avenues toward microRNA detection in vitro: a review of technical advances and challenges

C Zhu, L Zhu, D Tan, X Qiu, C Liu, S Xie… - Computational and …, 2019 - Elsevier
Over the decades, the biological role of microRNAs (miRNAs) in the post-transcriptional
regulation of gene expression has been discovered in many cancer types, thus initiating the …