Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a meta-…

Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity.
To identify adiposity loci whose effects are modified by PA, we performed genome-wide …

Small molecules are extensively metabolized and cleared by the kidney. Changes in serum
metabolite concentrations may result from impaired kidney function and can be used to …

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide.
Occasional cannabis use can progress to frequent use, abuse and dependence with all …

Individual risk of type 2 diabetes (T2D) is modified by perturbations to the mass, distribution
and function of adipose tissue. To investigate the mechanisms underlying these associations…

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic
disease and mortality, although little is known about the genetic variants influencing this trait…