User profiles for Lykke Sylow
 | Lykke SylowUniversity of Copenhagen Verified email at ifi.ku.dk Cited by 3727 |
Exercise-stimulated glucose uptake—regulation and implications for glycaemic control
Skeletal muscle extracts glucose from the blood to maintain demand for carbohydrates as
an energy source during exercise. Such uptake involves complex molecular signalling …
an energy source during exercise. Such uptake involves complex molecular signalling …
Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling
Insulin resistance is a major health risk, and although exercise clearly improves skeletal
muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a …
muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a …
[PDF][PDF] The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now
implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of …
implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of …
[HTML][HTML] Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity
SB Jorgensen, HM O'Neill, L Sylow, J Honeyman… - Diabetes, 2013 - Am Diabetes Assoc
Obesity is associated with chronic low-grade inflammation that contributes to defects in
energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 …
energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 …
Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance
Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and
Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. …
Rac1 are important regulators of insulin-stimulated glucose uptake in skeletal muscle. …
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-dependent
GLUT4 translocation. Muscle contraction increases glucose transport and …
GLUT4 translocation. Muscle contraction increases glucose transport and …
[HTML][HTML] Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial
DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial …
DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial …