Background The AIDS Clinical Trials Group protocol 076 zidovudine prophylaxis regimen
for HIV-1-infected pregnant women and their babies has been associated with a significant …

Background Oral pre-exposure prophylaxis has been introduced in more than 70 countries,
including many in sub-Saharan Africa, but women experience considerable barriers to daily …

Background In 1999, we reported safety and efficacy data for short-course nevirapine from a
Ugandan perinatal HIV-1 prevention trial when 496 babies were followed up to age 14–16 …

Background A universal testing and treatment strategy is a potential approach to reduce the
incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are …

Introduction Randomized clinical trials have demonstrated the efficacy of antiretroviral pre‐exposure
prophylaxis (Pr EP ) in preventing HIV acquisition among men who have sex with …

Background Bacterial vaginosis (BV) increases preterm delivery (PTD) risk, but treatment
trials showed mixed results in preventing PTD. Objectives Determine, using individual …

Background: Morbidity and mortality patterns among pregnant women and their infants (before
antiretroviral therapy was widely available) determines HIV-1 diagnostic, monitoring, and …

Viral genetic sequencing can be used to monitor the spread of HIV drug resistance, identify
appropriate antiretroviral regimes, and characterize transmission dynamics. Despite …

OBJECTIVE: The use of antibiotics to prevent preterm birth has achieved mixed results. Our
goal in this study was to determine if antibiotics given prenatally and during labor reduce the …

Methods: The HIV Prevention Trials Network 057 protocol was a phase 1, open-label study
of the pharmacokinetics and safety of tenofovir disoproxil fumarate (TDF) in HIV-infected …