Understanding the cell–cell interactions that control CNS development and function has long
been limited by the lack of methods to cleanly separate neural cell types. Here we describe …

Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in
response to all CNS injuries and diseases. To better understand the reactive astrocyte state, we …

To achieve its precise neural connectivity, the developing mammalian nervous system
undergoes extensive activity-dependent synapse remodelling. Recently, microglial cells have …

In the developing central nervous system (CNS), the control of synapse number and function
is critical to the formation of neural circuits. We previously demonstrated that astrocyte-…

To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and
myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL …

The inability to purify and culture astrocytes has long hindered studies of their function.
Whereas astrocyte progenitor cells can be cultured from neonatal brain, culture of mature …

… 4c). The hollow space inside the gel for fluid flow can be created with a temporary mold,
which is removed after gelling and before cell seeding. The mold can be solid rods or needles, …

Abstract Development, physiological functions, and pathologies of the brain depend on tight
interactions between neurons and different types of glial cells, such as astrocytes, microglia, …

Expansion of astrocyte populations in the central nervous system is characteristic of
evolutionarily more complex organisms. However, regulation of mammalian astrocyte precursor …

Disruption of the blood–brain barrier (BBB) leads to various neurovascular diseases.
Development of therapeutics required to cross the BBB is difficult due to a lack of relevant in vitro …