Purpose: Reovirus is a naturally occurring oncolytic virus in clinical trials. Although tumor
infection by reovirus can generate adaptive antitumor immunity, its therapeutic importance …

Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing
testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models …

Oncolytic viruses can exert their antitumor activity via direct oncolysis or activation of antitumor
immunity. Although reovirus is currently under clinical investigation for the treatment of …

Membrane-presented CD40 agonists can induce apoptosis in carcinoma, but not normal
homologous epithelial cells, whereas soluble agonists are growth inhibitory but not …

Background As well as inducing direct oncolysis, reovirus treatment of melanoma is associated
with activation of innate and adaptive anti-tumour immune responses. Results Here we …

Immunotherapy is showing promise for otherwise incurable cancers. Oncolytic viruses (OVs),
developed as direct cytotoxic agents, mediate their antitumor effects via activation of the …

Oncolytic virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated
tumor regression. Although the ability of oncolytic viruses to generate adaptive antitumor …

T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn,
facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated …

The naturally occurring oncolytic virus (OV), reovirus, replicates in cancer cells causing direct
cytotoxicity, and can activate innate and adaptive immune responses to facilitate tumour …

Background CNS tumors, including medulloblastoma and pediatric glioblastoma (pGBM)
account for the majority of solid pediatric malignancies. There remains an unmet need to …