Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here …

We developed molecular tension probes (TPs) that report traction forces of adherent cells
with high spatial resolution, can in principle be linked to virtually any surface, and obviate …

Targeted protein degradation with molecular glue degraders has arisen as a powerful
therapeutic modality for eliminating classically undruggable disease-causing proteins through …

The efficient extraction of (bio) molecules from fluid mixtures is vital for applications ranging
from target characterization in (bio) chemistry to environmental analysis and biomedical …

Molecular glues are an intriguing therapeutic modality that harness small molecules to induce
interactions between proteins that typically do not interact. However, such molecules are …

Targeted protein degradation (TPD) and proteolysis-targeting chimeras (PROTACs) have
arisen as powerful therapeutic modalities for degrading specific proteins in a proteasome-…

Protein therapeutics are a blossoming industry, with revenues exceeding $51 billion in 2005
and a growth rate nearly three times that of the overall pharmaceutical industry. Although it …

Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing
functional protein sites and compounds for therapeutic development. However, the vast …

We describe the development and validation of interaction determination using unpurified
proteins (IDUP), a method that selectively amplifies DNA sequences identifying ligand+target …

Interaction-dependent PCR (IDPCR) is a solution-phase method to identify binding partners
from combined libraries of small-molecule ligands and targets in a single experiment. …