The mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and
proliferation and is the target of rapamycin, a drug with many clinical uses 1 . mTORC1 …

The mTOR complex 1 (mTORC1) pathway promotes cell growth in response to many cues,
including amino acids, which act through the Rag guanosine triphosphatases (GTPases) to …

Leucine is a proteogenic amino acid that also regulates many aspects of mammalian
physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master …

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth
regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, …

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag
GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase …

The mTORC1 kinase is a master growth regulator that senses numerous environmental
cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell
growth that responds to numerous environmental cues. A key input is amino acids, which …

Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic
target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular …

For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient-…

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell
growth that responds to diverse environmental signals and is deregulated in many human …