We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) is inevitable in
metastatic EGFR-mutant lung cancers. Here, we modeled disease progression using EGFR-…

… (Lynnette Fernandez-Cuesta and Ruping Sun, personal communication). In brief, paired-end
RNAseq reads were mapped onto hg19 using a sensitive gapped aligner, GSNAP 30 . …

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other
lung cancers, but their precise relationship has remained unclear. Here we perform a …

Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing data, …

We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of
25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas …

Purpose: To identify novel mechanisms of resistance to third-generation EGFR inhibitors in
patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or …

Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis
surveillance but it may also play a crucial role in the detection of pre-clinical cancer. Small-…