INTRODUCTION Cytotoxic T lymphocytes (CTLs) are important cells within the immune
system that are able to recognize and destroy cancer and virally infected cells. Killing is …

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin
network to drive the polarized secretion of lytic granules, initiating target cell death during the …

Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally
infected and cancerous targets by polarized release from secretory lysosomes. Upon target …

EROS (essential for reactive oxygen species) protein is indispensable for expression of
gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a …

EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of
the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase. EROS deficiency in …

Increasing global rates of autoimmune and inflammatory disease present a burgeoning threat
to human health. This is compounded by the limited efficacy of available treatments and …

CD8 cytotoxic T lymphocytes (CTL) rely on rapid reorganization of the branched F-actin
network to drive the polarized secretion of lytic granules, initiating target cell death during the …

… Lyra O. Randzavola et al. has found that mutations in the ARPC1B gene can lead to various
immune disorders, including immunodeficiency, which is characterized by susceptibility to …

The dynamic visualization of developing immunological synapses has been hindered by
the difficulty of imaging the contact between the T cell and the antigen-presenting cell (APC). …

Tissue-resident memory T cells (T RM ) are noncirculating immune cells that contribute to
the first line of local defense against reinfections. Their location at hotspots of pathogen …