[HTML][HTML] A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease
…, B Vardarajan, S Amad, N Amin, MA Ikram… - Alzheimer's & …, 2019 - Elsevier
Introduction The genetic architecture of Alzheimer's disease (AD) is only partially understood.
Methods We conducted an association study for AD using whole sequence data from 507 …
Methods We conducted an association study for AD using whole sequence data from 507 …
[HTML][HTML] Primary prevention of cardiovascular disease: The past, present, and future of blood pressure-and cholesterol-lowering treatments
MJG Leening, MA Ikram - PLoS Medicine, 2018 - journals.plos.org
In a Perspective, M. Afran Ikram and Maarten Leening discuss the evolving approaches to
determining cardiovascular risk.
determining cardiovascular risk.
Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities
…, N Jahanshad, S Li, MA Logue, M Luciano, M Scholz… - bioRxiv, 2019 - biorxiv.org
We conducted a genome-wide association meta-analysis of two ischemic white matter
disease subtypes in the brain, periventricular and deep white matter hyperintensities (PVWMH …
disease subtypes in the brain, periventricular and deep white matter hyperintensities (PVWMH …
Age at natural menopause and life expectancy with and without type 2 diabetes
E Asllanaj, A Bano, L Jaspers, EJ Sijbrands, MA Ikram… - Maturitas, 2017 - maturitas.org
Background: Early onset of menopause is associated with increased risk of type 2 diabetes (T2D)
and all-cause mortality. However, little is known about the effects of early age at …
and all-cause mortality. However, little is known about the effects of early age at …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Retinal vessel diameters and risk of hypertension: the Rotterdam Study
MK Ikram, JCM Witteman, JR Vingerling… - …, 2006 - Am Heart Assoc
Generalized retinal arteriolar narrowing is an important sign of systemic hypertension, and a
lower arteriolar:venular diameter ratio predicts the risk of hypertension. We investigated …
lower arteriolar:venular diameter ratio predicts the risk of hypertension. We investigated …
Towards a sustainable environment: The nexus between ISO 14001, renewable energy consumption, access to electricity, agriculture and CO2 emissions in SAARC …
In this study, we investigate complex, country-level relationships between ISO 14001 certification,
renewable energy consumption, access to electricity, agriculture, and CO 2 emissions …
renewable energy consumption, access to electricity, agriculture, and CO 2 emissions …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
Global prevalence and major risk factors of diabetic retinopathy
… The prevalence of any DR varied across ethnic groups and was highest among African
Americans and lowest among Asians. The prevalence of any DR increased with diabetes …
Americans and lowest among Asians. The prevalence of any DR increased with diabetes …
Retinal microvasculature as a model to study the manifestations of hypertension
The retinal vasculature allows direct noninvasive visualization of the body’s mircrovasculature.
Because the retina and other end organs (brain and kidney) share similar anatomical …
Because the retina and other end organs (brain and kidney) share similar anatomical …