Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage are …

Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological
disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of …

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by
autoimmune inflammation, demyelination, and axonal damage. MS etiology remains …

There is a long history of research into body fluid biomarkers in neurodegenerative and
neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical …

… M. Tintoré has received compensation for consulting services and speaking honoraria from
Bayer-Schering, Merck-Serono, Biogen-Idec, Teva, Sanofi, Genzyme, Almirall and Novartis…

Background: To evaluate whether oligoclonal bands (OB) add information to MRI in predicting
both a second attack and development of disability in patients with clinically isolated …

Objective: To determine the relation between baseline MRI and both conversion to multiple
sclerosis (MS) and development of disability in a cohort of patients with clinically isolated …

Objective Many patients with multiple sclerosis (MS) are currently receiving treatment with
interferon (IFN)–β. Early identification of nonresponder patients is crucial to try different …

Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS…

Background: Recently developed diagnostic criteria for MS (McDonald criteria) indicate that
in patients with a single demyelinating episode (clinically isolated syndromes [CIS]), …