Greasing their way: lipid modifications determine protein association with membrane rafts

I Levental, M Grzybek, K Simons - Biochemistry, 2010 - ACS Publications
Increasing evidence suggests that biological membranes can be laterally subdivided into
domains enriched in specific lipid and protein components and that these domains may be …

Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily.

W Diakowski, M Grzybek… - Folia histochemica et …, 2006 - journals.viamedica.pl
The review is focused on the domain structure and function of protein 4.1, one of the proteins
belonging to the membrane skeleton. The protein 4.1 of the red blood cells (4.1 R) is a …

Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids

A Czogalla, M Grzybek, W Jones, Ü Coskun - Biochimica et Biophysica …, 2014 - Elsevier
The cell membrane serves, at the same time, both as a barrier that segregates as well as a
functional layer that facilitates selective communication. It is characterized as much by the …

[PDF][PDF] Modulation of myelopoiesis progenitors is an integral component of trained immunity

…, M Grzybek, T Grinenko, A Eugster, M Troullinaki… - Cell, 2018 - cell.com
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary
challenge, despite their short lifespan in circulation. We thus hypothesized that trained …

Palmitoylation regulates raft affinity for the majority of integral raft proteins

I Levental, D Lingwood, M Grzybek… - Proceedings of the …, 2010 - National Acad Sciences
… 5 A and B); treatment with 20 mM DTT prior to ABE led to complete depalmitoylation (silver
signal at the same level as completely depalmitoylating treatment of 0.5 M HAM). Given the …

Regulation of human EGF receptor by lipids

Ü Coskun, M Grzybek, D Drechsel… - Proceedings of the …, 2011 - National Acad Sciences
The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase
receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. …

Raft domains of variable properties and compositions in plasma membrane vesicles

I Levental, M Grzybek, K Simons - Proceedings of the …, 2011 - National Acad Sciences
Biological membranes are compartmentalized for functional diversity by a variety of specific
protein–protein, protein–lipid, and lipid–lipid interactions. A subset of these are the …

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

…, D Grosser, T Kajikawa, B Wang, M Grzybek… - Nature …, 2019 - nature.com
Resolution of inflammation is essential for tissue homeostasis and represents a promising
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 (…

Cholesterol modulates glycolipid conformation and receptor activity

…, B Binnington, T Róg, I Vattulainen, M Grzybek… - Nature chemical …, 2011 - nature.com
We document a new dimension of surface recognition in which communication is controlled
through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid …

Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature

MM Kamal, D Mills, M Grzybek… - Proceedings of the …, 2009 - National Acad Sciences
In biological processes, such as fission, fusion and trafficking, it has been shown that lipids
of different shapes are sorted into regions with different membrane curvatures. This lipid …