Adverse intra- and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …

… × 100 % where F is Faraday's constant (96,485 C mol −1 ), m is the experimentally observed
mass (g), I is the current intensity (A), t is the electrolysis time (s), and M is the molar mass of …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of
patients with neurodegenerative diseases and have been implicated in mediating neuronal …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Background The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's
disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct …

Background: Pathologic changes in the Alzheimer disease (AD) brain occur in a hierarchical
neuroanatomical pattern affecting cortical, subcortical, and limbic regions. Objective: To …

Synucleinopathies including Parkinson's disease, dementia with Lewy bodies and multiple
system atrophy are characterized by the abnormal accumulation and propagation of α‐…

The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a
hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that …