INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Introduction There is a growing body of evidence that subtle deficits in instrumental activities
of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not …

Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of
the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer’s disease (AD). …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers
may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive …

Background Alzheimer's disease (AD) pathology is common in patients with amnestic mild
cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in patients …

Introduction We estimated the age-specific duration of the preclinical, prodromal, and dementia
stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (…