[HTML][HTML] Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11

K Kondás, G Szláma, M Trexler, L Patthy - Journal of biological chemistry, 2008 - ASBMB
WFIKKN1 and WFIKKN2 are large extracellular multidomain proteins consisting of a WAP, a
follistatin, an immunoglobulin, two Kunitz-type protease inhibitor domains, and an NTR …

The LCCL module

M Trexler, L Bányai, L Patthy - European Journal of …, 2000 - Wiley Online Library
Here we show that Lgl1 protein, cub‐1‐related proteins, coch‐5b2‐related proteins, coagulation
factor C of horse‐shoe crab and a predicted protein of Plasmodium falciparum share a …

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

G Szláma, K Kondás, M Trexler, L Patthy - The FEBS journal, 2010 - Wiley Online Library
WFIKKN1 and WFIKKN2 are large extracellular multidomain proteins consisting of a WAP
domain, a follistatin domain, an immunoglobulin domain, two Kunitz‐type protease inhibitor …

A human protein containing multiple types of protease-inhibitory modules

M Trexler, L Bányai, L Patthy - Proceedings of the National …, 2001 - National Acad Sciences
By using sensitive homology-search and gene-finding programs, we have found that a
genomic region from the tip of the short arm of human chromosome 16 (16p13.3) encodes a …

[HTML][HTML] NMR structure of the LCCL domain and implications for DFNA9 deafness disorder

E Liepinsh, M Trexler, A Kaikkonen, J Weigelt… - The EMBO …, 2001 - embopress.org
The LCCL domain is a recently discovered, conserved protein module named after its presence
in Limulus factor C, cochlear protein Coch-5b2 and late gestation lung protein Lgl1. The …

[HTML][HTML] Evolution of termination codons of proteins and the TAG-TGA paradox

M Trexler, L Bányai, K Kerekes, L Patthy - Scientific Reports, 2023 - nature.com
In most eukaryotes and prokaryotes TGA is used at a significantly higher frequency than
TAG as termination codon of protein-coding genes. Although this phenomenon has been …

Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22

…, E Leskinen, P Pamilo, M Trexler… - Proceedings of the …, 2000 - National Acad Sciences
Human DNA sequence variation data are useful for studying the origin, evolution, and
demographic history of modern humans and the mechanisms of maintenance of genetic variability …

Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules

M Trexler, L Bányai, L Patthy - 2002 - degruyter.com
We have recently identified a gene (the WFIKKN gene) on human chromosome 16 (16p13.3)
that encodes a secreted protein containing WAPtype, Follistatin/ Kazal type, Kunitztype and …

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN 1 than by WFIKKN 2

G Szláma, M Trexler, L Patthy - The FEBS Journal, 2013 - Wiley Online Library
Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin precursor
by multiple steps of proteolytic processing. After cleavage by a furin‐type protease, the …

[HTML][HTML] Peptide ligands for the fibronectin type II modules of matrix metalloproteinase 2 (MMP-2)

M Trexler, K Briknarová, M Gehrmann, M Llinás… - Journal of Biological …, 2003 - ASBMB
The interaction of matrix metalloproteinase 2 (MMP-2) with gelatin is mediated by three
repeats homologous to fibronectin type II (FN2) modules, which are inserted in the catalytic …