Although hatching from eggs is fundamental for nematode biology it remains poorly understood.
For animal-parasitic nematodes in particular, advancement has been slow since the …

Organoids are multicellular culture systems that replicate tissue architecture and function,
and are increasingly used as models of viral, bacterial, and protozoan infections. Organoids …

As a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces granulomatous
lung lesions and systemic inflammatory responses during active disease. Molecular …

Lung granulomas develop upon Mycobacterium tuberculosis (Mtb) infection as a hallmark
of human tuberculosis (TB). They are structured aggregates consisting mainly of Mtb-infected …

Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineage-specific
transcription factor Foxp3, and their main function is to suppress T cells. While …

Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health
problem in resource-limited settings and, despite decades of research, human responses to the …

The probabilistic expression of cytokine genes in differentiated T helper (Th) cell populations
remains ill defined. By single-cell analyses and mathematical modeling, we show that one …

By developing a high-density murine immunophenotyping platform compatible with high-throughput
genetic screening, we have established profound contributions of genetics and …

… Duque-Correa 1 Peter Ellis Peter Ellis 1 Tegegn G. Jaleta Tegegn G. Jaleta 6 Roz Laing
Roz Laing 7 Kirsty Maitland Kirsty Maitland 7 Catherine McCarthy Catherine McCarthy 1 …

The molecular basis of pathogen-induced host cell apoptosis is well characterized for a number
of microorganisms. Mycobacterium tuberculosis is known to induce apoptosis and it was …