[PDF][PDF] RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether

…, MA Czekalska, G Musteikyte, MA Gachechiladze… - Cell, 2019 - cell.com
Long-distance RNA transport enables local protein synthesis at metabolically-active sites
distant from the nucleus. This process ensures an appropriate spatial organization of proteins, …

[PDF][PDF] CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons

R Tian, MA Gachechiladze, CH Ludwig, MT Laurie… - Neuron, 2019 - cell.com
CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian
cell biology. However, most previous CRISPR-based screens were conducted in cancer …

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

…, M Prudencio, Y Carlomagno, MA Gachechiladze… - Science, 2019 - science.org
INTRODUCTION Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)
are fatal neurodegenerative diseases that share clinical and neuropathological features. …

Apolipoprotein E genotype affects size of ApoE complexes in cerebrospinal fluid

NM Heinsinger, MA Gachechiladze… - … of Neuropathology & …, 2016 - academic.oup.com
Apolipoprotein E (apoE) is associated with lipoproteins in the cerebrospinal fluid (CSF).
APOE4 increases and APOE2 decreases the risk for Alzheimer disease (AD) compared to the …

Calling Cards: A Customizable Platform to Longitudinally Record Protein‐DNA Interactions Over Time in Cells and Tissues

…, S Sarafinovska, MA Gachechiladze… - Current …, 2023 - Wiley Online Library
Calling Cards is a platform technology to record a cumulative history of transient protein‐DNA
interactions in the genome of genetically targeted cell types. The record of these …

Unilateral contact problems with friction for hemitropic elastic solids

A Gachechiladze, R Gachechiladze, D Natroshvili - 2009 - degruyter.com
We study three-dimensional unilateral contact problems with friction for hemitropic elastic
solids. We give their mathematical formulation in the form of spatial variational inequalities and …

Neurodevelopmental Genetic Associations Across the Translational Space-Time Continuum

MA Gachechiladze… - Biological …, 2024 - biologicalpsychiatryjournal.com
Genes encoding machinery for synaptic development and plasticity have been shown to
play a role in the pathophysiology of neurodevelopmental psychiatric disorders such as …

Quantifying causal influences in the presence of a quantum common cause

M Gachechiladze, N Miklin, R Chaves - Physical Review Letters, 2020 - APS
Quantum mechanics challenges our intuition on the cause-effect relations in nature. Some
fundamental concepts, including Reichenbach’s common cause principle or the notion of …

The regional development problems of Transcaucasia

RG Gachechiladze, MA Nadzhafaliyev, AD Rondeli - Geoforum, 1984 - Elsevier
This article examines the economic development of three distinctive republics (Georgian
SSR, Armenian SSR, Azerbaydzhan SSR) on the periphery of the USSR Planned as three …

Correction: Calling Cards: A Customizable Platform to Longitudinally Record Protein-DNA Interactions Over Time in Cells and Tissues

…, S Sarafinovska, MA Gachechiladze… - Current …, 2023 - pubmed.ncbi.nlm.nih.gov
… Allen Yen, Chase Mateusiak, Simona Sarafinovska, Mariam A Gachechiladze, Juanru
Guo, Xuhua Chen, Arnav Moudgil, Alexander J Cammack, Jessica Hoisington-Lopez …