Intracerebral hemorrhage is the second most common subtype of stroke. In recent decades
our understanding of intracerebral hemorrhage has improved. New risk factors have been …

Background Exercise may be a promising target for depression interventions. However,
evidence for a beneficial effect of exercise interventions on the prevention of depression differs …

Introduction: The cognitive reserve hypothesis suggests that across the lifespan, higher
education, regular participation in social or mentally stimulating activities, and complexity of …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

The pattern of structural brain alterations associated with major depressive disorder (MDD)
remains unresolved. This is in part due to small sample sizes of neuroimaging studies …

… unit director12, Rebecca Hardy professor of epidemiology and medical statistics and MRC
programme leader12, Andre G Uitterlinden professor of complex genetics10, M Arfan Ikram …

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …

Background and Purpose—We previously reported on the high prevalence of cerebral
microbleeds (CMBs) in community-dwelling people aged 60 years and older. Moreover, we found …