Foreword This Journal feature begins with a case vignette highlighting a common clinical
problem. Evidence supporting various strategies is then presented, followed by a review of …

Although the majority of patients with obsessive compulsive disorder can be helped
significantly by modern pharmacotherapy, usually in combination with behavioral techniques of …

Background Case reports suggest that neurosurgical operations can improve symptoms in
patients with severe treatment-refractory obsessive-compulsive disorder (OCD). However, it is …

… Specialized hardware (Media 100, Marlboro, MA) was used to transfer the digital PICT
information to videotape synchronized with the headsweeps of the VCR so as not to distort the …

Dorsal anterior cingulate cortex (dACC) is a brain region that subserves cognition and motor
control, but the mechanisms of these functions remain unknown. Human neuroimaging and …

Background: Previous studies have used symptom provocation and positron emission
tomography to delineate the brain systems that mediate various anxiety states. Using an …

Background: The study was designed to determine the mediating neuroanatomy of
obsessive-compulsive disorder (OCD). Methods: The short half-life tracer oxygen 15—labeled …

Background: The anterior cingulate cognitive division (ACcd) plays a central role in
attentional processing by: 1) modulating stimulus selection (ie, focusing attention) and/or 2) …

We developed the MGH Hairpulling Scale to provide a brief, self-report instrument for assessing
repetitive hairpulling. Seven individual items, rated for severity from 0 to 4, assess urges …

… Informed consent was obtained following the established guidelines of the Massachusetts …
Functional MRI scanning techniques developed by the Massachusetts General Hospital NMR …