Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …

TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we
investigate the interaction of two endogenous modulators with TRPV5. Both …

10.7554/eLife.03606.001 Voltage-gated ion channels generate electrical currents that control
muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-…

Electroporation or electropermeabilization is a technique that enables transient increase in
the cell membrane permeability by exposing cells to pulsed electric field. However, the …

Biomolecular simulations are intrinsically high dimensional and generate noisy data sets of
ever-increasing size. Extracting important features from the data is crucial for understanding …

Many endogenous peptides rely on signaling pathways to exert their function, but identifying
their cognate receptors remains a challenging problem. We investigate the use of AlphaFold…

In contrast to most voltage-gated ion channels, hyperpolarization- and cAMP gated (HCN)
ion channels open on hyperpolarization. Structure-function studies show that the voltage-…

Voltage sensor domains (VSDs) are membrane-bound protein modules that confer voltage
sensitivity to membrane proteins. VSDs sense changes in the transmembrane voltage and …

In voltage-gated potassium (K V ) channels, the voltage-sensing domain (VSD) undergoes
sequential activation from the resting state to the intermediate state and activated state to …

… Ion passage through pores formed in the system was determined by a custom MATLAB (The
MathWorks, Natick, MA) code based on the positions of ions extracted from the trajectories. …