The Liver X Receptors (LXRα, NR1H3; LXRβ, NR1H2) encode highly homologous transcription
factors that are members of the nuclear receptor superfamily of proteins. Both LXRα and …

BACKGROUND Disparities in healthcare access and delivery, caused by transportation and
health workforce difficulties, negatively impact individuals living in rural areas. These …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

We examined the incidence and clinical and economic consequences of primary
hyperparathyroidism in residents of Rochester, Minn., from 1965 through 1976; 90 cases were found. …

The molecular basis of nephronophthisis 1 , the most frequent genetic cause of renal failure
in children and young adults, and its association with retinal degeneration and cerebellar …

The measurement of dipolar contributions to the splitting of 15N resonances of 1H-15N amide
pairs in multidimensional high-field NMR spectra of field-oriented cyanometmyoglobin is …

… fat/high-cholesterol diet was not limited to the lung or to macytes represent the major cell …
play an important role in mediating cholesterol efflux from macrophages and preventing …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Importance Clostridium difficileis a major cause of health care–associated infection, but
disagreement between diagnostic tests is an ongoing barrier to clinical decision making and …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …