BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains
a major scientific and medical challenge. Emerging genomic technologies now permit the …

Aging is a mysterious process, not only controlled genetically but also subject to random
damage that can accumulate over time. While DNA damage and subsequent mutation in …

Developmental programs are controlled by transcription factors and chromatin regulators,
which maintain specific gene expression programs through epigenetic modification of the …

… Lodato et al. also found that neurons take on somatic mutations as they age by sequencing
single neurons from subjects aged 4 months to 82 years. Somatic mutations accumulated …

Dementia in Alzheimer’s disease progresses alongside neurodegeneration 1 , 2 , 3 – 4 , but
the specific events that cause neuronal dysfunction and death remain poorly understood. …

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage.
Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human …

Elucidating how chromatin influences gene expression patterns and ultimately cell fate is
fundamental to understanding development and disease. The histone variant H2AZ has …

The study of induced pluripotency is complicated by the need for infection with high-titer
retroviral vectors, which results in genetically heterogeneous cell populations. We generated …

Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic
epigenome, particularly through demonstrations of direct lineage reprogramming of one …

Little empirical research has focused specifically on the process of identifying comprehensive
training needs for department chairs and school directors in public universities. A case …